WebDec 1, 2024 · Importantly, knockdown of RBM24 in human embryonic stem cell-derived cardiomyocytes showed similar electrophysiological abnormalities, suggesting the … WebAug 21, 2024 · Background: RNA-binding proteins plays critical roles in several post-transcriptional regulatory processes. The RNA-binding protein, Rbm24, has been shown to be involved in the development of the heart and skeletal muscles by regulating different post-transcriptional processes such as splicing and stabilization of specific target mRNAs.

Cells Free Full-Text RNA-Binding Protein Rbm24 as a Multifaceted

WebOct 13, 2014 · RBM24 Regulates Alternative Splicing in the Heart. To investigate whether RBM24 is involved in the regulation of alternative splicing, we analyzed the transcriptome of WT and RBM24 −/− mutant hearts by RNA sequencing (RNA-seq) (n = 3). To avoid potential secondary changes, hearts of E11.5 embryos were used because no discernable … WebRNA binding motif protein 24 (RBM24) is a tissue-specific RBP which is highly expressed in human and mouse heart. Previous studies demonstrated the functional role of RBM24 in … cite this for me manchester harvard

RBM24 is a major regulator of muscle-specific alternative

WebThe first identified RBP with a role in alternative splicing during heart failure was alternative splicing factor 1 (ASF/SF2), regulating the remodeling-induced splicing switch of CaMKIIδ. … WebRBM24 in the foetal heart, foetal skeletal muscle, and adult heart (Figure 1B). These data suggested that RBM24 is an early marker of cardiac differentiation and a heart-enriched gene. WebAug 29, 2014 · rbm24a and rbm24b are expressed in somites and presumptive skeletal muscle populations. We initially identified Rbm24 in a screen for early cardiac genes and demonstrated it to be expressed at multiple time points during mouse cardiogenesis as well as in the somites (9.5 dpc) .Our subsequent cardiovascular-focused studies in zebrafish … cite this for me me