Ephrin type-a receptor 10
WebThe ephrin-B-EphB family plays a critical role in the maintenance of bone homeostasis. Ephrin-Eph signaling is bidirectional; thus, the binding between ligand and receptor triggers a signal transduction cascade downstream of both molecules (Fig. 3.10).The bidirectional nature of ephrin-Eph signaling is the basis of its role in coupling bone resorption to bone … WebMar 9, 2024 · Enables GPI-linked ephrin receptor activity and growth factor binding activity. Involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of phosphatidylinositol 3-kinase activity. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron …
Ephrin type-a receptor 10
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Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their … See more Ephs can be divided into two subclasses, EphAs and EphBs (encoded by the genetic loci designated EPHA and EPHB respectively), based on sequence similarity and on their binding affinity for either the See more The extracellular domain of Eph receptors is composed of a highly conserved globular ephrin ligand-binding domain, a cysteine-rich region and two fibronectin type III domains. The cytoplasmic domain of Eph receptors is composed of a juxtamembrane … See more The Eph receptors were initially identified in 1987 following a search for tyrosine kinases with possible roles in cancer, earning their name from the erythropoietin-producing hepatocellular carcinoma cell line from which their cDNA was obtained. These … See more The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development. Bi-directional signaling Unlike most other … See more • Eph+Family+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more
WebFeb 7, 2010 · General Function. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway … WebEphrin-Eph signaling is based on the binding of ephrin molecules to their cognate ephrin receptors on the surface of adjacent cells. There are two families of ephrins: ephrin-A …
Web产品信息. Recombinant human Ephrin-A3/EFNA3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ser 213) of human Ephrin-A3/EFNA3 (Accession #NP_004943.1.) fused with and a 6×His tag at the C-terminus. Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. WebSep 22, 2009 · Function. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact …
WebAug 18, 2024 · Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple functions. The tyrosine kinase EphA2, which belongs to the family of Eph receptors, is highly produced in tumor tissues, while found at relatively low levels in most normal adult tissues, indicating …
WebEphrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene. Function. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are … broward school district jobsWebDec 12, 2024 · The subclass of Ephrin-type A receptors/Ephrin-type A (EphA/EphrinA) are implicated as regulators of insulin secretion 6. Eph receptors are the largest known family of receptor protein–tyrosine ... broward school district budgetWebAbstract The Eph receptors are the largest known family of receptor tyrosine kinases. Initially all of them were identified as orphan receptors without known ligands, and their specific functions were not well understood. During the past few years, a corresponding family of ligands has been identified, called the ephrins, and specific functions have now … everest court weshamWebJan 5, 2024 · Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in … everest corporate bankingWebNov 30, 2016 · Eph receptors are known to form multimeric signaling clusters upon binding to their ephrin ligands. These clusters may include more than one receptor type that, even when not bound to ephrin, become phosphorylated (Wimmer-Kleikamp et al., 2004). Progranulin is secreted as a dimer, and, in principle, up to 14 granulin modules are … everest corporate edition keyWebJan 20, 2024 · The ephrin type-A receptor 2 (EphA2) detects β-glucan and plays a central role in stimulating epithelial cells to release proinflammatory mediators during OPC. The epidermal growth factor receptor (EGFR) … broward school districtWebExpression of the receptor tyrosine kinase ephrin receptor A10 (EphA10), which is undetectable in most normal tissues except for the male testis, has been shown to … broward school clever password