Ctgf in diabetic nephropathy
WebMar 27, 2024 · The diabetic chronic kidney disease (CKD) model in this study utilized uninephrectomy, high fat diet and one dose of streptozotocin which closely simulates human type 2 diabetic nephropathy. 25, 26 Male Sprague–Dawley rats (body weight 225–250 g, Charles River) were subjected to right nephrectomy under inhaled isoflurane anesthesia. WebOct 14, 2014 · CTGF is upregulated in the human kidney during a variety of kidney diseases, including diabetic nephropathy, chronic allograft nephropathy, hypertensive …
Ctgf in diabetic nephropathy
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WebMar 16, 2024 · Microalbuminuria is a hallmark of early stage diabetic nephropathy and usually indicates damage to the glomerular filtration barrier due to ultrastructural changes in podocytes and glomerular endothelial cells rather than alterations in glomerular pressure or filtration rate alone. ... and profibrotic markers (Collagen I and CTGF) DM-N Nakamura ... WebNov 14, 2012 · Diabetic nephropathy, also known as Kimmelstiel-Wilson syndrome or nodular diabetic glomerulosclerosis or intercapillary glomerulonephritis, is a clinical syndrome characterized by albuminuria (>300 mg/day or >200 mcg/min) confirmed on at least two occasions 3-6 months apart, permanent and irreversible decrease in glomerular …
WebFeb 2, 2008 · CTGF was first identified as a potential player in the molecular network of the diabetic glomerulus, when it was shown by subtractive hybridization that its expression was upregulated in mesangial cells exposed to high glucose.3 Furthermore, CTGF expression was upregulated in podocytes and mesangial cells in several animal models of diabetic … WebIn a previous study, we found a significant decrease in vascular endothelial growth factor A (VEGF-A) mRNA levels in glomeruli from patients with diabetic nephropathy (DN). We …
WebSep 23, 2024 · Diabetic nephropathy (DN) is a representative complication of diabetes and is a leading cause of end-stage renal disease [].DN is characterized by aberrant … WebOct 5, 2024 · Kidney fibrosis is the main pathologic change in diabetic nephropathy (DN), which is the major cause of end-stage renal disease. ... Abbreviations: CTGF, connective tissue growth factor; DM, diabetic model; IHC, immunohistochemistry; PASM, periodic …
WebOct 1, 2001 · Immunohistochemistry detected CTGF protein in glomeruli of kidneys of non-obese diabetic mice 14 days after the onset of diabetes, and this was prominent by 70 days. CTGF protein is also present in glomeruli of human patients with diabetic nephropathy. No CTGF was detected in either normal murine or human glomeruli.
WebAug 9, 2024 · Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is also a serious microvascular complication of diabetes and the main cause of end-stage renal disease (ESRD) in developed and developing countries. Renal fibrosis is a finally pathological change in DN. canned butter beans nutrition factsWebNov 16, 2004 · Connective tissue growth factor (CTGF, CCN2) CTGF is involved in extracellular matrix remodelling during development and in pathological conditions, and … canned butternut squash soup recipeWebJan 1, 2006 · CTGF is considered to be of particular interest to diabetic nephropathy because its expression is induced by high glucose and because it mediates transforming … fix my microsoft wordWebSep 29, 2014 · Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. … canned cake for saleWebApr 12, 2024 · Obesity-related glomerulopathy and diabetic nephropathy (DN) are serious complications to metabolic syndrome and diabetes. The purpose was to study effects of a fat, fructose and cholesterol-rich ... fix my microwaveWebJun 1, 2008 · CTGF is a secreted protein and can be detected in biological fluids. Previous small studies have reported that both urinary CTGF excretion and plasma CTGF levels … canned by alex shearer summaryWebFeb 27, 2024 · TGF-β1 is a key factor for pathophysiological processes in DKD. In both type 1 and type 2 diabetes, increased tubular and glomerular TGF-β expression is found in the early as well as late phase of the disease [ 84 ]. TGF-β-mediated effects influence the pathology of mesangial cells, podocytes, and endothelial and tubular cells. canned button mushrooms for sale